Dr. Carlos Isales, MD

• Endocrinology, Diabetes & Metabolism

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Yale New Haven Hospital

  Fellowship Hospital, 1988

• San Juan Va Hospital

  Residency Hospital, 1985

• San Juan Va Hospital

  Internship Hospital, 1983

• University Of Puerto Rico School Of Medicine

  Medical School, 1982

• Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss, 2017-08-03

• Amino Acids as Signaling Molecules Modulating Bone Turnover, 2018-02-27

• Accumulation of Kynurenine elevates oxidative stress and alters microRNA Profile in Human Bone Marrow Stromal Cells, 2019-11-30

• Renal Contributions to Age-Related Changes in Mineral Metabolism Irsik et al., 2021-06-03

• Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis, 2020-12-10

• What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands, 2019-02-10

• Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis, 2017-05-17

• Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton, 2019-11-19

• Kynurenine, a Tryptophan Metabolite that Accumulates with Age, Induces Bone Loss, 2017-08-14

• Synergistic Effects of Multiple Factors Involved in COVID-19-dependent Muscle Loss, 2022-04-01

• A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice, 2021-05-08

• Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells, 2018-02-08

• Lower hand grip strength in older adults with non-alcoholic fatty liver disease: a nationwide population-based study, 2019-07-07

• Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview, 2021-10-05

• Kynurenine suppresses osteoblastic cell energeticsin vitroand osteoblast numbersin vivo, 2019-12-17

• Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation, 2019-10-13

• Age-associated changes in microRNAs affect the differentiation potential of human mesenchymal stem cells: Novel role of miR-29b-1-5p expression, 2021-08-14

• Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection, 2021-02-01

• The Positive Association of Total Protein Intake with Femoral Neck Strength (KNHANES IV), 2018-03-06

• Expression of long noncoding RNAXistis induced by glucocorticoids, 2022-09-14

• The glucocorticoid receptor in Osterix-expressing cells regulates bone mass, bone marrow adipose tissue, and systemic metabolism in female mice during aging, 2021-11-24

• Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment, 2019-04-07

• Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: a nationwide population-based study, 2018-08-16

• Long Non-coding RNA MALAT1 Is Depleted With Age in Skeletal Musclein vivoand MALAT1 Silencing Increases Expression of TGF-ß1in vitro, 2022-01-21

• Nanostring-Based Identification of the Gene Expression Profile in Trigger Finger Samples, 2021-11-20

• Kynurenine Promotes RANKL-Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway, 2020-10-26

• Male sex hormones, aging, and inflammation, 2023-01-04

• Differentially Expressed Genes in PPAR?-deficient MSCs, 2017-07-31

• Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells, 2019-03-25

• Association of Dietary Niacin Intake with Incident Hip Fracture, BMD and Body Composition: The Cardiovascular Health Study, 2019-01-19

• Deletion of Protein Kinase D1 in Osteoprogenitor Cells Results in Decreased Osteogenesisin vitroand Reduced Bone Mineral Densityin vivo, 2017-08-12

• COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile, 2020-04-28

• Proteomic Analysis of Female Synovial Fluid to Identify Novel Biomarkers for Osteoarthritis, 2023-02-22

• Alteration in Nasopharyngeal Microbiota Profile in Aged Patients with COVID-19, 2021-09-05

• The Role of Tryptophan Metabolites in Musculoskeletal Stem Cell Aging, 2020-09-11

• Stromal cell-derived Factor-1 (CXCL12) and its role in bone and muscle biology, 2019-07-20

• Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss, 2019-01-17

• The glucocorticoid receptor in osteoprogenitors regulates bone mass and marrow fat, 2019-07-01

• Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption, 2019-11-01

• Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview, 2018-12-07

• Chemically Defined and Xeno-Free Cryopreservation of Human Adipose-Derived Stem Cells, 2016-03-24

• MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells., 2020-10-03