Dr. Donald O'Rourke Jr, MD

• Neurosurgery

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• University Of Pennsylvania Perelman School Of Medicine

  Medical School, 1987

• Subcellular Genomics: Pervasive within-mitochondrion SNV heteroplasmy revealed by single mitochondrion sequencing, 2017-12-05

• Factors Associated with Increased Survival after Surgical Resection of Glioblastoma in Octogenarians, 2015-05-15

• Immune landscapes associated with different glioblastoma molecular subtypes, 2019-11-29

• PD1 Expression in EGFRvIII-Directed CAR T Cell Infusion Product for Glioblastoma Is Associated with Clinical Response, 2022-05-06

• Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases, 2015-12-01

• Quantification of tumor microenvironment acidity in glioblastoma using principal component analysis of dynamic susceptibility contrast enhanced MR imaging, 2021-07-22

• Differentiation between Glioblastomas and Solitary Brain Metastases Using Diffusion Tensor Imaging, 2008-10-07

• Engineering Chimeric Antigen Receptor T cells to Treat Glioblastoma, 2017-11-06

• A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma, 2019-07-18

• MRI-Based Radiomics Combined with Deep Learning for Distinguishing IDH-Mutant WHO Grade 4 Astrocytomas from IDH-Wild-Type Glioblastomas, 2023-02-02

• Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyondIDH1, 2018-03-23

• Three-dimensional echo planar spectroscopic imaging for differentiation of true progression from pseudoprogression in patients with glioblastoma, 2018-12-17

• Immunological features inde novoand recurrent glioblastoma associate with survival outcomes, 2022-07-01

• High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms, 2021-09-10

• SPROUTY2 DRIVES DRUG RESISTANCE AND PROLIFERATION IN GLIOBLASTOMA, 2015-05-01

• Transcriptome signatures associated with meningioma progression, 2019-04-30

• Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma, 2018-11-27

• Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma, 2016-04-14

• Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy, 2017-02-13

• Cancer Imaging Phenomics via CaPTk: Multi-Institutional Prediction of Progression-Free Survival and Pattern of Recurrence in Glioblastoma, 2020-03-19

• Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2a, 2018-02-08

• Multivariate Analysis of Preoperative Magnetic Resonance Imaging Reveals Transcriptomic Classification ofde novoGlioblastoma Patients, 2019-12-12

• IDH mutation impairs histone demethylation and results in a block to cell differentiation, 2012-02-15

• Mechanisms of resistance to CAR T cell therapies, 2019-12-19

• Evaluating the Association Between the Extent of Resection and Survival in Gliosarcoma, 2019-04-03

• Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma, 2020-11-30

• In vivo detection of EGFRvIII in glioblastoma via perfusion magnetic resonance imaging signature consistent with deep peritumoral infiltration: thefindex, 2017-04-20

• Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma, 2019-06-19

• The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells, 2009-05-08

• Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity, 2009-03-17

• Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases, 2015-10-31

• Imaging and histopathologic correlates of plasma cell-free DNA concentration and circulating tumor DNA in adult patients with newly diagnosed glioblastoma, 2020-02-27

• Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma, 2021-05-07

• A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity, 2019-12-26

• Pattern Analysis of Dynamic Susceptibility Contrast MRI Reveals Peritumoral Tissue Heterogeneity, 2014-06-19

• Circulating glioma cells exhibit stem cell-like properties, 2018-10-15

• Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma, 2022-05-24

• Glioblastoma: the current state of biology and therapeutic strategies, 2022-03-01

• A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma, 2017-07-19

• Clinical utility of plasma cell-free DNA in adult patients with newly diagnosed glioblastoma - a pilot prospective study, 2019-10-30

• Primary cell culture of live neurosurgically-resected aged adult human brain cells and single cell transcriptomics, 2017-01-17

• Non-Invasive Assessment of Isocitrate Dehydrogenase-Mutant Gliomas Using Optimized Proton Magnetic Resonance Spectroscopy on a Routine Clinical 3-Tesla MRI, 2023-09-07

• Reversion of the ErbB Malignant Phenotype and the DNA Damage Response, 2012-09-27

• The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics, 2022-07-29

• PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma, 2018-08-27

• Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development, 2018-07-09