Dr. Jack Roth, MD

• Cardiothoracic Surgery

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• Johns Hopkins School Of Medicine

  Medical School, 1971

• Tumor Suppressor Gene-Based Nanotherapy: From Test Tube to the Clinic, 2011-01-24

• Gene Silencing by Gold Nanoshell-Mediated Delivery and Laser-Triggered Release of Antisense Oligonucleotide and siRNA, 2012-08-13

• AP2ß nucleolar localization predicts poor survival after stage I non-small cell lung cancer resection, 2012-01-19

• Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer, 2018-11-26

• Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities, 2021-01-21

• Genetic Variations in Epigenetic Genes Are Predictors of Recurrence in Stage I or II Non-Small Cell Lung Cancer Patients, 2012-01-15

• Prognostic Significance of Combinations of RNA-Dependent Protein Kinase and EphA2 Biomarkers for NSCLC, 2013-01-25

• Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity, 2009-02-08

• Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung CancerIn VitroandIn Vivo, 2010-11-29

• Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380, 2014-08-14

• Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380, 2014-11-16

• Genetic Variations in the Regulator of G-Protein Signaling Genes Are Associated with Survival in Late-Stage Non-Small Cell Lung Cancer, 2011-06-17

• Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities, 2017-11-01

• Predictors for Locoregional Recurrence for Clinical Stage III-N2 Non-small Cell Lung Cancer with Nodal Downstaging After Induction Chemotherapy and Surgery, 2012-12-20

• Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites, 2016-02-10

• 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib, 2023-05-11

• Radiographic response to neoadjuvant therapy in pleural mesothelioma should serve as a guide for patient selection for cytoreductive operations, 2023-08-11

• Stereotactic Ablative Radiotherapy for Operable Stage I Non-Small Cell Lung Cancer: Long-Term Results of the Single-Arm STARS Prospective Trial, 2021-09-13

• Surgical outcomes after neoadjuvant nivolumab or nivolumab with ipilimumab in patients with non-small cell lung cancer, 2022-01-23

• Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer, 2021-02-03

• Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer, 2020-02-17

• RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer, 2015-03-14

• Major pathologic response and RAD51 predict survival in lung cancer patients receiving neoadjuvant chemotherapy, 2018-04-19

• TUSC2 downregulates PD-L1 expression in non-small cell lung cancer (NSCLC), 2017-11-21

• Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment, 2021-08-24

• Relax with CouchDB - Into the non-relational DBMS era of Bioinformatics, 2012-05-17

• Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients, 2015-07-13

• Predictors of Survival in Never-Smokers with Non-Small Cell Lung Cancer: A Large-Scale, Two-Phase Genetic Study, 2012-09-13

• MicroRNA-mediated target mRNA cleavage and 3'-uridylation in human cells, 2016-07-21

• Ionizing radiation-induced ?-H2AX activity in whole blood culture and the risk of lung cancer, 2013-01-08

• IGFBP2/FAK pathway is causally associated with dasatinib resistance in non-small Cell Lung Cancer Cells, 2013-10-15

• CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts, 2022-07-29

• Stereotactic Ablative Radiotherapy: A Potentially Curable Approach to Early-Stage Multiple Primary Lung Cancer, 2013-06-24

• Inflammation-related Genetic Variations and Survival for Advanced Non-Small Cell Lung Cancer Receiving First-line Chemotherapy, 2014-04-22

• LKB1/STK11Expression in Lung Adenocarcinoma and Associations with Patterns of Recurrence, 2020-05-19

• Tumor characteristics associated with engraftment of patient-derived non-small cell lung cancer xenografts in immunocompromised mice, 2019-07-09

• Serum MicroRNA-150 Predicts Prognosis for Early-Stage Non-Small Cell Lung Cancer and Promotes Tumor Cell Proliferation by Targeting Tumor Suppressor GeneSRCIN1, 2017-10-16

• Phase I Clinical Trial of Systemically AdministeredTUSC2(FUS1)-Nanoparticles Mediating Functional Gene Transfer in Humans, 2012-04-25

• Landscape of EGFR -dependent and -independent resistance mechanisms to osimertinib and continuation therapy post-progression in EGFR-mutant NSCLC, 2018-09-18

• TUSC2 immunogene enhances efficacy of chemo-immuno combination on KRAS/LKB1 mutant NSCLC in humanized mouse model, 2022-02-24

• Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts, 2021-01-07

• Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells, 2017-03-02

• A Prospective Phase 2 Study of Surgery Followed by Chemotherapy and Radiation for Superior Sulcus Tumors, 2011-06-28

• Telomere Length in Peripheral Blood Leukocytes and Lung Cancer Risk: A Large Case-Control Study in Caucasians, 2014-03-11

• Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells, 2015-12-09

• Author Correction: 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib, 2023-06-06

• Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer, 2014-11-18

• Insulin-Like Growth Factor Binding Protein-2 Level Is Increased in Blood of Lung Cancer Patients and Associated with Poor Survival, 2013-09-17

• The Tumor Suppressor Gene TUSC2 (FUS1) Sensitizes NSCLC to the AKT Inhibitor MK2206 in LKB1-dependent Manner, 2013-10-17

• TUSC2immunogene therapy synergizes with anti-PD-1 through enhanced proliferation and infiltration of natural killer cells in syngeneicKras-mutant mouse lung cancer models, 2018-01-16

• Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers, 2013-05-23

• Pathway-based serum microRNA profiling and survival in patients with advanced-stage non-small cell lung cancer, 2013-06-17

• Early metabolic change after induction chemotherapy predicts histologic response and prognosis in patients with esophageal cancer: Secondary analysis of a randomized trial, 2017-12-09

• From clinical specimens to human cancer preclinical models-a journey the NCI-cell line database-25 years later, 2019-12-05

• Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment, 2022-01-07

• Author Correction: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts, 2021-02-19

• Circulating metabolite profiles to predict overall survival in advanced non-small cell lung cancer patients receiving first-line chemotherapy, 2017-11-02

• Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal Growth Factor Receptor (EGFR) Lung Cancer Cells through Context Specific Pathways Resulting in Enhanced Therapeutic Efficacy, 2015-06-08

• Genetic Variants in Inflammation-Related Genes Are Associated with Radiation-Induced Toxicity Following Treatment for Non-Small Cell Lung Cancer, 2010-08-25

• Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S., 2016-05-27

• Variants with low allele frequency detected in genomic DNA affect the accuracy of mutation detection in cell-free DNA by next-generation sequencing, 2017-11-27

• MiRNA-Related Genetic Variations Associated with Radiotherapy-Induced Toxicities in Patients with Locally Advanced Non-Small Cell Lung Cancer, 2016-03-18

• KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer, 2013-07-03

• Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial, 2021-02-18

• Therapeutic Targeting of the PI4K2A/PKR Lysosome Network is Critical for Misfolded Protein Clearance and Survival in Cancer Cells, 2019-09-25

• MicroRNA-Related Genetic Variants Associated with Clinical Outcomes in Early Stage Non-Small Cell Lung Cancer Patients, 2013-02-01

• An improved patient-derived xenograft humanized mouse model for evaluation of lung cancer immune responses, 2019-06-11

• Telomere length and recurrence risk after curative resection in patients with early-stage non-small cell lung cancer: a prospective cohort study, 2014-11-14

• LKB1 mutations in NSCLC are associated with KEAP1/NRF2-dependent radiotherapy resistance targetable by glutaminase inhibition, 2020-12-15

• Cationic liquid crystalline nanoparticles for the delivery of synthetic RNAi-based therapeutics, 2017-06-09

• Preoperative Maximum Standardized Uptake Value Associated with Recurrence Risk In Early Lung Cancer, 2021-07-09

• Tumor cellular proliferation is associated with enhanced immune checkpoint expression in stage I non-small cell lung cancer, 2019-05-17

• Combined MEK/MDM2 inhibition demonstrates antitumor efficacy inTP53wild-type thyroid and colorectal cancers with MAPK alterations, 2022-01-24

• Clinical outcome and predictors of survival and pneumonitis after stereotactic ablative radiotherapy for stage I non-small cell lung cancer, 2012-09-10

• Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells?, 2012-02-22

• Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis, 2018-11-06

• STAT3 mediates resistance to MEK inhibitor through microRNA miR-17, 2011-03-28

• 7-year Follow-Up Outcomes after Stereotactic Ablation Radiotherapy for Stage I NSCLC: Results of a Phase ? Clinical Trial, 2017-03-27

• TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin, 2016-11-15