Dr. James Meigs, MD

• Internal Medicine

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• Harvard Medical School

  Medical School, 1989

• A low-frequency inactivatingAKT2variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk, 2017-03-24

• An expanded genome-wide association study of type 2 diabetes in Europeans, 2017-05-31

• Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose, 2020-05-07

• A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance, 2012-05-13

• GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification, 2023-09-07

• Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants inLAMA1and Enrichment for Risk Variants in Lean Compared to Obese Cases, 2012-05-31

• Identifying primary care patients at risk for future diabetes and cardiovascular disease using electronic health records, 2009-09-22

• The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations, 2009-03-31

• Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls, 2019-05-22

• A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study, 2007-09-19

• Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program, 2021-02-10

• Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes, 2018-04-09

• Precision subclassification of type 2 diabetes: a systematic review, 2023-10-05

• Association between muscle mass and diabetes prevalence independent of body fat distribution in adults under 50 years old, 2022-05-28

• Plasma resistin, adiponectin, and risk of incident atrial fibrillation: The Framingham Offspring Study, 2011-11-17

• Peri-Aortic Fat Deposition Is Associated with Peripheral Arterial Disease: The Framingham Heart Study, 2010-07-16

• Electronic Medical Record Cancer Incidence over Six Years Comparing New Users of Glargine with New Users of NPH Insulin, 2014-10-20

• Association of a 62 Variant Type 2 Diabetes Genetic Risk Score with Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study, 2015-03-24

• Leveraging family history in genetic association analyses of binary traits, 2022-10-01

• The Genetic Epidemiology of Type 2 Diabetes: Opportunities for Health Translation, 2019-07-22

• Sugar-Sweetened Beverages and Prevalence of the Metabolically Abnormal Phenotype in the Framingham Heart Study, 2014-03-08

• Is Genetic testing useful to predict type 2 diabetes?, 2014-05-17

• Multiple Biomarkers and Risk of Clinical and Subclinical Vascular Brain Injury: The Framingham Offspring Study, 2012-03-28

• Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis, 2017-09-12

• Sequence data and association statistics from 12,940 type 2 diabetes cases and controls, 2017-12-19

• Adipocytokines as Features of the Metabolic Syndrome Determined Using Confirmatory Factor Analysis, 2013-03-25

• Glycated Albumin and Direct Low Density Lipoprotein Cholesterol Levels in Type 2 Diabetes Mellitus, 2009-05-22

• Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability, 2021-01-05

• Association of Levels of Fasting Glucose and Insulin with Rare Variants at the Chromosome 11p11.2-MADDLocus: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study, 2014-05-07

• A Decade of Genetic and Metabolomic Contributions to Type 2 Diabetes Risk Prediction, 2017-11-04

• Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose, 2018-04-06

• Omega-3 polyunsaturated fatty acid and insulin sensitivity: A meta-analysis of randomized controlled trials, 2011-09-29

• Variants in theCNR1and theFAAHgenes and adiposity traits in the community, 2009-01-22

• A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels, 2022-10-24

• Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19, 2022-07-21

• Discordant Risk: Overweight and cardiometabolic risk in Chinese adults, 2012-06-25

• Insulin resistance since early adulthood and appendicular lean mass in middle-aged adults without diabetes: 20 years of the CARDIA study, 2018-09-17

• Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease, 2014-01-17

• Clear detection ofADIPOQlocus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals, 2009-12-02

• Successful Outcomes of a Clinical Decision Support System in an HIV Practice: A Randomized Controlled Trial, 2012-12-04

• Determinants of Smoking and Quitting in HIV-Infected Individuals, 2016-04-21

• Race-ethnic differences in the association of genetic loci with HbA1clevels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III), 2012-04-27

• A Genome-Wide Association Study Reveals Variants inARL15that Influence Adiponectin Levels, 2009-12-11

• Selection of the Most Informative Individuals from Families with Multiple Siblings for Association Studies, 2009-03-06

• Sequence Kernel Association Test for Quantitative Traits in Family Samples, 2012-12-26

• Directional dominance on stature and cognition in diverse human populations, 2015-07-01

• Magnesium Intake Is Inversely Associated With Coronary Artery Calcification The Framingham Heart Study, 2013-11-27

• Potential Interplay Between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome, to Modulate Insulin Resistance and Diabetes Risk: insights from a Meta-Analysis of 19,005 Individuals, 2019-09-12

• Material need insecurities, diabetes control, and care utilization: Results from the Measuring Economic iNsecurity in Diabetes (MEND) study, 2015-06-24

• Genetic variation inGIPRinfluences the glucose and insulin responses to an oral glucose challenge, 2010-01-17

• Total and High-Molecular Weight Adiponectin and Resistin in Relation to the Risk for Type 2 Diabetes in Women: A Prospective Study, 2008-09-02

• Hypertension and diabetes: co-prediction and time trajectories, 2018-01-15

• A Phenomics-Based Strategy Identifies Loci onAPOC1,BRAP, andPLCG1Associated with Metabolic Syndrome Phenotype Domains, 2011-10-13

• Genome-wide association with diabetes-related traits in the Framingham Heart Study, 2007-09-19

• Loci for insulin processing and secretion provide insight into type 2 diabetes risk, 2023-01-23

• Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis, 2020-06-15

• Yogurt consumption is associated with better diet quality and metabolic profile in American men and women, 2012-12-27

• Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program, 2020-08-25

• Smoking Behavior among US Adults with Diabetes or Impaired Fasting Glucose, 2013-04-15

• Association of smoking cessation and weight change with cardiovascular disease among people with and without diabetes, 2013-03-13

• The Association of Maximum Body Weight on the Development of Type 2 Diabetes and Microvascular Complications: MAXWEL Study, 2013-12-04

• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis, 2011-04-12

• Variants in the melatonin receptor 1B gene (MTNR1B) influence fasting glucose levels, 2008-12-07

• Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms, 2016-02-23

• Body mass index and diabetes risk in fifty-seven low- and middle-income countries: a cross-sectional study of nationally representative individual-level data, 2021-07-17

• Genetic Counseling as a Tool for Type 2 Diabetes Prevention: A Genetic Counseling Framework for Common Polygenetic Disorders, 2013-07-29

• A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease, 2015-05-28

• Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes, 2021-06-09

• Cardiovascular Risk Prediction Functions Underestimate Risk in HIV Infection, 2018-02-14

• Age at type 2 diabetes onset and glycaemic control: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2010, 2013-09-01

• Genome-wide association study and functional characterisation identifies candidate genes for insulin-stimulated glucose uptake, 2023-06-08

• Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis, 2021-03-04

• Food Insecurity, Healthcare Utilization, and High Cost: A Longitudinal Cohort Study, 2019-01-03

• Lack of association between the Trp719Arg polymorphism in kinesin-like protein 6 and coronary artery disease in 19 case-control studies, 2010-11-02

• Links between ectopic fat and vascular disease in humans, 2014-07-17

• Periaortic Adipose Tissue and Aortic Dimensions in the Framingham Heart Study, 2012-12-19

• Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization, 2022-10-07

• Consequences of the COVID-19 Pandemic: Reduced Hemoglobin A1c Diabetes Monitoring Diabetes Monitoring During COVID-19, 2021-02-02

• Type 2 Diabetes Risk in Persons with Dysglycemia: The Framingham Offspring Study, 2011-01-15

• Fasting and Post-Glucose Load Measures of Insulin Resistance and Risk of Ischemic Stroke in Older Adults, 2011-10-13

• Fatty Liver is Associated With Dyslipidemia and Dysglycemia Independent of Visceral Fat: The Framingham Heart Study, 2010-12-02

• Genome-wide association with select biomarker traits in the Framingham Heart Study, 2007-09-19

• Genome-wide polygenic score to predict chronic kidney disease across ancestries, 2022-06-16

• Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies, 2011-05-12

• Susceptibility to type 2 diabetes mellitus -from genes to prevention, 2014-02-18

• Predictors of health facility readiness for diabetes service delivery in low- and middle-income countries: The case of Bangladesh, 2020-09-04

• Trends in food insecurity for adults with cardiometabolic disease in the United States: 2005-2012, 2017-06-07

• Metabolic factors and genetic risk mediate familial type 2 diabetes risk in the Framingham Heart Study, 2015-01-27

• General Framework for Meta-Analysis of Haplotype Association Tests, 2016-03-08

• Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways, 2012-08-12

• Revisiting heritability accounting for shared environmental effects and maternal inheritance, 2014-11-09

• Cross-sectional association of dietary patterns with insulin resistance phenotypes among adults without diabetes in the Framingham Offspring Study, 2009-02-16

• Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies, 2021-06-14

• A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation, 2022-06-02

• Plasma Levels of Fatty Acid-Binding Protein 4, Retinol-Binding Protein 4, High-Molecular Weight Adiponectin, and Cardiovascular Mortality among Men with Type 2 Diabetes: A 22-Year Prospective Study, 2016-09-08

• Predicted 25-hydroxyvitamin D Score and Change in Fasting Plasma Glucose in the Framingham Offspring Study, 2011-10-19

• Robust analysis of secondary phenotypes in case-control genetic association studies, 2016-05-30

• The Trans-Ancestral Genomic Architecture of Glycemic Traits, 2021-05-31

• A Risk Score for Chronic Kidney Disease in the General Population, 2011-10-19

• Predictors of Incident Albuminuria in the Framingham Offspring Cohort, 2011-10-11

• Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci, 2015-11-09

• Genome-Wide Association Study for Circulating Tissue Plasminogen Activator (tPA) Levels and Functional Follow-up Implicates EndothelialSTXBP5andSTX2, 2014-02-27

• Parent-of-Origin Effects of theAPOBGene on Adiposity in Young Adults, 2015-10-09

• Common variants in and nearIRS1and subclinical cardiovascular disease in the Framingham Heart Study, 2013-04-22

• Ordered Stratification to Reduce Heterogeneity in Linkage to Diabetes-Related Quantitative Traits, 2008-07-24

• Ambient Air Pollution, Adipokines, and Glucose Homeostasis: The Framingham Heart Study, 2017-12-20

• Elevated ischemic stroke risk among women living with HIV infection, 2018-01-02

• Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis, 2017-11-02

• Abdominal Subcutaneous and Visceral Adipose Tissue and Insulin Resistance in the Framingham Heart Study, 2010-03-25

• Design of a Randomized Trial of Diabetes Genetic Risk Testing to Motivate Behavior Change: The Genetic Counseling/Lifestyle Change (GC/LC) Study to Prevent Diabetes, 2013-07-24

• Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps, 2018-10-08

• Meta-analysis of Gene-Environment interaction: joint estimation of SNP and SNP×Environment regression coefficients, 2012-02-03

• Predicting Virologic Failure in an HIV Clinic, 2010-03-01

• Massachusetts general hospital Covid-19 registry reveals two distinct populations of hospitalized patients by race and ethnicity, 2020-12-22

• Pleiotropic genes for metabolic syndrome and inflammation, 2014-05-09

• Identification and Functional Characterization ofG6PC2Coding Variants Influencing Glycemic Traits Define an Effector Transcript at theG6PC2-ABCB11Locus, 2015-01-27

• Genetic association tests in family samples for multi-category phenotypes, 2021-12-04

• Genomic approach to therapeutic target validation identifies a glucose-loweringGLP1Rvariant protective for coronary heart disease, 2016-06-01

• Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation, 2022-05-12

• Mapping Quantitative Traits in Unselected Families: Algorithms and Examples, 2009-02-17

• Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals, 2012-03-29

• The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports, 2007-09-19

• Incorporating gene-environment interaction in testing for association with rare genetic variants, 2014-07-18

• Convex Combination Sequence Kernel Association Test for Rare Variant Studies, 2020-02-26

• A Long Non-coding RNA,LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3BMetabolic Traits and Type 2 Diabetes Risk Locus, 2020-07-10

• Association between Inflammatory Biomarkers and Bone Mineral Density in a Community-based Cohort of Men and Women: The Framingham Osteoporosis Study, 2014-02-03

• Assessing the phenotypic effects in the general population of rare variants in genes for a dominant mendelian form of diabetes, 2013-10-06

• Approximate conditional phenotype analysis based on genome wide association summary statistics, 2021-01-28

• Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes, 2012-08-12

• Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability, 2021-02-08

• Relations of Circulating Resistin and Adiponectin and Cardiac structure and Function: the Framingham Offspring study, 2011-02-24

• The genetic architecture of type 2 diabetes, 2016-08-04

• Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program, 2022-07-28

• Risk of type 2 diabetes and cumulative excess weight exposure in the framingham offspring study?, 2013-01-10

• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk, 2010-01-17

• Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility, 2015-01-29

• Association of C-Reactive Protein and HIV Infection With Acute Myocardial Infarction, 2009-07-01

• Association of Acculturation and Health Literacy with Prevalent Dysglycemia and Diabetes Control Among Latinos in the Boston Area Community Health (BACH) Survey, 2016-07-13

• Exome-wide association study of plasma lipids in >300,000 individuals, 2017-10-30

• Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals, 2019-07-01

• Association of African genetic ancestry with fasting glucose and HbA1clevels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study, 2014-06-19

• Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations, 2022-06-29

• An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis, 2019-06-13

• Documentation of body mass index and control of associated risk factors in a large primary care network, 2009-12-16

• Racial differences in long-term adherence to oral antidiabetic drug therapy: a longitudinal cohort study, 2009-02-07

• A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies, 2022-10-27

• Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes and coronary heart disease, 2011-06-02