Dr. Jann Sarkaria, MD

• Radiation Oncology

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• University Hi J A Burns School Med|university Of Wi Hospital And Cli

  Residency Hospital

• Perivascular Stromal Cells Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model, 2022-09-15

• Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells, 2017-02-03

• Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme, 2015-06-16

• Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells, 2019-11-14

• Peak learning of mass spectrometry imaging data using artificial neural networks, 2021-09-20

• Challenges in the delivery of therapies to melanoma brain metastases, 2016-11-09

• ZD6474, a Multitargeted Inhibitor for Receptor Tyrosine Kinases, Suppresses Growth of Gliomas Expressing an Epidermal Growth Factor Receptor Mutant, EGFRvIII, in the Brain, 2010-04-06

• Visualizing cancer and response to therapyin vivousing Cy5.5-labeled factor VIIa and anti-tissue factor antibody, 2014-12-16

• EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180, 2013-06-03

• Quantitative phosphoproteomics reveals Wee1 kinase as a therapeutic target in a model of proneural glioblastoma, 2016-05-17

• Expression of the of the androgen receptor governs radiation resistance in a subset of glioblastomas vulnerable to anti-androgen therapy, 2020-08-12

• Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion, 2013-02-14

• Investigating Dependencies of Relative Biological Effectiveness for Proton Therapy in Cancer Cells, 2018-03-21

• Discordant in vitro and in vivo chemo-potentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts, 2014-05-16

• The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasion, 2021-12-03

• Attenuating hypoxia driven malignant behavior in glioblastoma with a novel hypoxia-inducible factor 2 alpha inhibitor, 2020-09-16

• Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy, 2022-04-01

• A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma, 2023-07-10

• DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme, 2016-10-28

• MDM2 Inhibition in the Treatment of Glioblastoma: From Concept to Clinical Investigation, 2023-07-02

• Image-based metric of invasiveness predicts response to adjuvant temozolomide for primary glioblastoma, 2020-03-27

• ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL, 2020-11-17

• The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma, 2022-02-08

• Drug Delivery to Melanoma Brain Metastases: Can Current Challenges Lead to New Opportunities?, 2017-06-17

• IL-13Ra2 Status Predicts GB-13 (IL13.E13K-PE4E) Efficacy in High-Grade Glioma, 2022-04-24

• SGEF is Regulated via TWEAK/Fn14/NF-?B Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide, 2016-01-13

• Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs, 2015-05-12

• Automatic 3D Non-linear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data, 2019-04-22

• Brain Tumor Initiating Cells Adapt to Restricted Nutrition through Preferential Glucose Uptake, 2013-09-01

• Combination of temsirolimus (CCI-779) with chemo-radiation in newly diagnosed GBM (NCCTG trial N027D) is associated with increased infectious risks1, 2010-10-04

• Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts, 2012-06-06

• Active efflux of dasatinib from the brain limits efficacy against murine glioblastoma: broad implications for the clinical use of molecularly-targeted agents, 2012-08-13

• Addressing BBB Heterogeneity: A New Paradigm for Drug Delivery to Brain Tumors, 2020-12-11

• Src family kinases differentially influence glioma growth and motility, 2015-06-10

• Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues, 2018-03-27

• Brain Tumor Stem Cell Multipotency Correlates with Nanog Expression and Extent of Passaging in Human Glioblastoma Xenografts, 2013-06-08

• Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas, 2020-12-10

• Expression of CD74 in high Grade Gliomas: A Potential Role in Temozolomide Resistance, 2010-05-05

• Editorial: Targeted Therapies for Glioblastoma: A Critical Appraisal, 2019-11-12

• Drug and disease signature integration identifies synergistic combinations in glioblastoma, 2018-12-14

• Gene Expression Profiling of NF1-Associated and Sporadic Pilocytic Astrocytoma Identifies Aldehyde Dehydrogenase 1 Family, Member L1 (ALDH1L1) as an Underexpressed Candidate Biomarker in Aggressive Subtypes, 2009-01-28

• Restricted delivery of talazoparib across the blood-brain barrier limits the sensitizing effects of poly (ADP-ribose) polymerase inhibition on temozolomide therapy in glioblastoma, 2017-09-25

• Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition, 2022-06-03

• Protein kinase C?and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities, 2021-11-23

• Integrative multi-omics networks identify PKCd and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy, 2023-02-02

• p53 Small Molecule Inhibitor Enhances Temozolomide Cytotoxic Activity against Intracranial Glioblastoma Xenografts, 2008-12-15

• Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins, 2016-03-10

• Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses, 2015-05-01

• In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling, 2021-03-30

• Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival, 2017-09-14

• EGFRvIII Tumorigenicity Requires PDGFRA Co-Signaling and Reveals Therapeutic Vulnerabilities in Glioblastoma, 2021-03-11

• Hirsutinolide series inhibit Stat3 activity, alter GCN1, MAP1B, Hsp105, G6PD, vimentin, TrxR1, and importin a-2 expression, and induce antitumor effects against human glioma, 2015-09-17

• Quantifying Glioblastoma Drug Response Dynamics Incorporating Treatment Sensitivity and Blood Brain Barrier Penetrance From Experimental Data, 2020-08-21

• ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells, 2012-10-03

• Effective sensitization of temozolomide by ABT-888 is lost with development of TMZ resistance in glioblastoma xenograft lines, 2009-01-27

• Radiosensitizing effects of TMZ observedin vivoonly in a subset ofMGMTmethylated GBM xenografts, 2009-09-01

• Barriers to Effective Drug Treatment for Brain Metastases: A Multifactorial Problem in the Delivery of Precision Medicine, 2018-07-12

• ATR inhibition is a promising radiosensitizing strategy for triple negative breast cancer, 2018-08-30

• Methylation-dependent Tissue Factor suppression contributes to the reduced malignancy of IDH1 mutant gliomas, 2018-09-28

• ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: a Multi-disciplinary Team-based, Multifactorial Analytical Approach, 2020-07-02

• Correction to: Phase I-II trial of imatinib mesylate (Gleevec; STI571) in treatment of recurrent oligodendroglioma and mixed oligoastrocytoma. North central cancer treatment group study N0272 (ALLIANCE/NCCTG), 2019-07-17

• Primary resistance to EGFR inhibition in glioblastoma is mediated by a TNF-JNK-Axl-ERK signaling axis, 2017-06-12

• Modeling Therapy-Driven Evolution of Glioblastoma with Patient-Derived Xenografts, 2022-11-09

• Moving Beyond the Standard of Care: Accelerate Testing of Radiation-Drug Combinations, 2021-08-25

• Influence of Hyaluronic Acid Transitions in Tumor Microenvironment on Glioblastoma Malignancy and Invasive Behavior, 2018-06-26

• Targeting the RhoGEF ßPIX/COOL-1 in Glioblastoma: Proof of Concept Studies, 2020-11-26

• IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling, 2018-09-19

• Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist, 2016-05-13

• Localized metabolomic gradients in patient-derived xenograft models of glioblastoma, 2019-11-25

• Genomic and phenotypic characterization of a broad panel of patient derived xenografts reflects the diversity of glioblastoma, 2019-12-18

• Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition, 2018-03-22

• Phase I/II Trial of Temsirolimus and Sorafenib in Treatment of Patients with Recurrent Glioblastoma: North Central Cancer Treatment Group Study/Alliance N0572, 2018-01-03

• Purine metabolism regulates DNA repair and therapy resistance in glioblastoma, 2020-07-30

• Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways, 2017-01-06

• Network Modeling Identifies Patient-specific Pathways in Glioblastoma, 2016-06-29

• The efficacy of the Wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma, 2015-01-21

• Efficacy of PARP inhibitor rucaparib in orthotopic glioblastoma xenografts is limited by ineffective drug penetration into the central nervous system, 2015-10-05

• Misregulated E-Cadherin Expression Associated with an Aggressive Brain Tumor Phenotype, 2010-10-27

• Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors, 2019-07-04

• Glut3 addiction is a druggable vulnerability for a molecularly defined subpopulation of glioblastoma, 2017-11-30

• MARQUIS: A Multiplex Method for Absolute Quantification of Peptides and Post-Translational Modifications, 2015-01-12

• Nanocell-mediated delivery of miR-34a counteracts temozolomide resistance in glioblastoma, 2021-03-25

• Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens, 2019-07-19

• Impairment of Glioma Stem Cell Survival and Growth by a Novel Inhibitor for Survivin-Ran Protein Complex, 2012-12-18

• A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine, 2018-08-06

• LPA signaling is regulated through the primary cilium: a novel target in glioblastoma, 2018-01-11

• InsR/IGF1R pathway mediates resistance to EGFR inhibitors in glioblastoma, 2015-11-11

• Efficacy of the MDM2 inhibitor SAR405838 in glioblastoma is limited by poor distribution across the blood-brain barrier, 2018-07-03

• Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma, 2018-11-21

• WWP2 is an E3 ubiquitin ligase for PTEN, 2011-05-01

• An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1, 2010-01-19

• Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma, 2020-04-16

• Peptide Carrier-Mediated Non-Covalent Delivery of Unmodified Cisplatin, Methotrexate and Other Agents via Intravenous Route to the Brain, 2014-05-21

• Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model, 2020-11-18

• Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining, 2021-02-17

• Radiation Therapy Oncology Group 9802: Controversy or Consensus in the Treatment of Newly Diagnosed Low-Grade Glioma?, 2015-02-21

• Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells, 2019-02-27

• Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells, 2021-06-10

• Posttranscriptional Regulation ofPER1Underlies the Oncogenic Function of IREa, 2013-06-10

• Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas, 2023-06-20

• Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition, 2015-05-05

• Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers, 2021-08-14

• A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma, 2018-07-27

• PHASE I-II TRIAL OF IMATINIB MESYLATE (GLEEVEC; STI571) IN TREATMENT OF RECURRENT OLIGODENDROGLIOMA AND MIXED OLIGOASTROCYTOMA. NORTH CENTRAL CANCER TREATMENT GROUP STUDY N0272 (ALLIANCE/NCCTG), 2019-05-22

• Evaluation of MGMT Promoter Methylation Status and Correlation with Temozolomide Response in Orthotopic Glioblastoma Xenograft Model, 2008-11-15

• Extracellular Hyaluronic Acid Influences the Efficacy of EGFR Tyrosine Kinase Inhibitors in a Biomaterial Model of Glioblastoma, 2017-08-02

• Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation, 2014-04-10

• Oncolytic measles virus strains have significant antitumor activity against glioma stem cells, 2012-08-23

• Quantitative analysis of tyrosine phosphorylation from FFPE tissues reveals patient-specific signaling networks, 2021-05-20

• PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity, 2019-01-22

• EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR amplified glioblastoma by suppressing invasion through BIN3 upregulation, 2022-08-01

• NCCTG Phase I Trial N057K of Everolimus (RAD001) and Temozolomide in Combination with Radiation Therapy in Newly Diagnosed Glioblastoma Multiforme Patients1, 2010-09-23