Dr. Mark Fleming, MD

• Hematology

• Pediatric Endocrinology, Diabetes & Metabolism

• Hematopathology

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• Brigham And Women's Hospital

  Residency Hospital

• Postdoctural Fellow, Boston Children's Hospital, Hematology/oncology

  Fellowship Hospital, 2009

• Senior Resident, Brigham & Women's Hospital, Surgical Pathology

  Residency Hospital, 1996

• Brigham & Women's Hospital, Hematopathology

  Fellowship Hospital, 1996

• Brigham & Women's Hospital, Hematopathology|postdoctural Fellow, Boston Children's Hospital, Hematology/oncology

  Fellowship Hospital, 1996

• Brigham & Women's Hospital

  Internship Hospital, 1995

• Brigham & Women's Hospital, Anatomic Pathology

  Residency Hospital, 1995

• Brigham & Women's Hospital, Anatomic Pathology|brigham And Women's Hospital|senior Resident, Brigham & Women's Hospital, Surgical Pathology

  Residency Hospital, 1995

• Harvard Medical School

  Medical School, 1993

• University Of Oxford, Dphil, Organic Chemistry

  1990

• Princeton University

  Undergraduate School, 1987

• Characterization of mitochondrial ferritin-deficient mice, 2012-03-23

• SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1, 2014-06-09

• Pancreatic lipomatosis in Diamond-Blackfan anemia: The importance of genetic testing in bone marrow failure disorders, 2018-09-06

• A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency, 2015-12-07

• Systematic Molecular Genetic Analysis of Congenital Sideroblastic Anemia: Evidence for Genetic Heterogeneity and Identification of Novel Mutations, 2010-03-15

• Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis, 2015-02-05

• Hereditary Xerocytosis Revisited, 2014-07-21

• Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria, 2020-09-02

• Modulation of hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches, 2014-01-18

• DPP9 deficiency: an Inflammasomopathy which can be rescued by lowering NLRP1/IL-1 signaling, 2022-09-16

• UBE2O remodels the proteome during terminal erythroid differentiation, 2017-08-04

• X-linked sideroblastic anemia due toALAS2intron 1 enhancer element GATA binding site mutations, 2013-11-20

• SBDS Protein Expression Patterns in the Bone Marrow, 2010-07-15

• The IRP1-HIF-2a Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption, 2013-02-05

• Pediatric Aplastic Anemia and Refractory Cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors, 2015-03-02

• Myelodysplastic syndrome and acute myeloid leukemia in patients with Shwachman Diamond syndrome: a multicentre, retrospective, cohort study, 2019-12-23

• Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells, 2023-06-29

• A murine model of chronic lymphocytic leukemia based on B cell-restricted expression ofSf3b1mutation andAtmdeletion, 2019-01-31

• T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1 and ICAM1 Leading to a Blockade of Tumor Cell Intravasation, 2010-10-19

• Induced pluripotent stem cells with a pathological mitochondrial DNA deletion, 2013-03-05

• Congenital X-linked Neutropenia with Myelodysplasia and Somatic Tetraploidy due to a Germline Mutation in SEPT6, 2021-11-03

• A high throughput MALDI-TOF mass spectrometry method for quantification of hepcidin in human urine, 2010-02-15

• MUTATION UPDATE SLC25A38 SLC25A38 Congenital Sideroblastic Anemia: Phenotypes and genotypes of 31 individuals from 24 families, including 11 novel mutations, and a review of the literature, 2021-08-05

• HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis, 2013-02-05

• Physiologic expression of SF3B1K700Ecauses impaired erythropoiesis, aberrant splicing, and sensitivity to pharmacologic spliceosome modulation, 2016-09-12

• RINGED SIDEROBLASTS IN ß-THALASSEMIA, 2016-11-03

• Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome, 2021-02-26

• Mitochondrial Atpif1 regulates heme synthesis in developing erythroblasts, 2012-11-07

• Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2, 2012-03-28

• Pseudouridine synthase 1 deficient mice, a model for Mitochondrial Myopathy with Sideroblastic Anemia, exhibit muscle morphology and physiology alterations, 2016-05-20

• Heme transport and erythropoiesis, 2013-02-14

• Iron Overload in Patients with Acute Leukemia or MDS Undergoing Myeloablative Stem Cell Transplantation, 2010-09-18

• QTLs for murine red blood cell parameters in LG/J and SM/J F2and advanced intercross lines, 2012-02-10

• Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia, 2013-07-16