Dr. Naoto Ueno, MD

• Medical Oncology

• Internal Medicine

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• Wakayama Prefectural Medical College

  Medical School, 1999

• A Brief Review of the Biophysical Hallmarks of Metastatic Cancer Cells, 2013-08-01

• MEK inhibitor selumetinib (AZD6244; ARRY-142886) prevents lung metastasis in a triple-negative breast cancer xenograft model, 2015-09-17

• Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model, 2015-03-20

• BRCAMutations in Women with Inflammatory Breast Cancer, 2017-10-17

• Uncovering the molecular secrets of Inflammatory Breast Cancer biology: An integrated analysis of three distinct Affymetrix gene expression data sets, 2013-02-08

• Cooperative effect of oncogenicMETandPIK3CAin an HGF-dominant environment in breast cancer, 2018-12-05

• NDRG1 Expression Is an Independent Prognostic Factor in Inflammatory Breast Cancer, 2020-12-10

• A phase II study of talimogene laherparepvec for patients with inoperable locoregional recurrence of breast cancer, 2021-11-15

• Histone deacetylase inhibitor-induced cancer stem cells exhibit high pentose phosphate pathway metabolism, 2016-04-07

• Association between weight gain during adjuvant chemotherapy for early-stage breast cancer and survival outcomes, 2017-10-10

• Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression, 2021-07-09

• Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer, 2017-08-15

• Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance, 2021-06-10

• Predictors of durable no evidence of disease status in de novo metastatic inflammatory breast cancer patients treated with neoadjuvant chemotherapy and post-mastectomy radiation, 2014-03-31

• Imaging Features of Triple-Negative Breast Cancers According to Androgen Receptor Status, 2019-03-21

• Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin, 2020-02-24

• A phase Ib study of entinostat plus lapatinib with or without trastuzumab in patients with HER2-positive metastatic breast cancer that progressed during trastuzumab treatment, 2019-05-17

• c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through up-regulation of Notch1 via activation of c-Jun, 2016-12-12

• Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer, 2017-01-17

• Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer, 2021-01-15

• Serum HER2 levels determined by two methods in patients with metastatic breast cancer, 2011-05-25

• Reverse phase protein array identification of triple-negative breast cancer subtypes and comparison with mRNA molecular subtypes, 2017-07-31

• Location of Receipt of Initial Treatment and Outcomes in Long-Term Breast Cancer Survivors, 2017-01-13

• Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer, 2020-05-22

• Status of the anaplastic lymphoma kinase (ALK) gene in inflammatory breast carcinoma, 2013-08-28

• Retrospective analysis of anti tumor effects of zoledronic acid in breast cancer patients with bone-only metastases, 2011-12-02

• Prognostic Impact of Phosphorylated HER-2 in HER-2+Primary Breast Cancer, 2011-06-28

• MMP2 and MMP9 serum levels are associated with favorable outcome in patients with inflammatory breast cancer treated with bevacizumab-based neoadjuvant chemotherapy in the BEVERLY-2 study, 2016-02-23

• ST8SIA1 regulates tumor growth and metastasis in TNBC by activating the FAK-AKT-mTOR signaling pathway, 2018-09-20

• Identification of triple-negative breast cancer cell lines classified under the same molecular subtype using different molecular characterization techniques: Implications for translational research, 2020-04-30

• ONC201 and an MEK Inhibitor Trametinib Synergistically Inhibit the Growth of Triple-Negative Breast Cancer Cells, 2021-10-07

• PI3K and MAPK Pathways as Targets for Combination with the Pan-HER Irreversible Inhibitor Neratinib in HER2-Positive Breast Cancer and TNBC by Kinome RNAi Screening, 2021-06-28

• Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC, 2020-05-18

• Overall survival differences between patients with inflammatory and noninflammatory breast cancer presenting with distant metastasis at diagnosis, 2015-05-29

• Impact of 21-gene RT-PCR assay on adjuvant therapy and outcomes in patients with stage I breast cancer, 2015-06-18

• Inflammatory breast cancer appearance at presentation is associated with overall survival, 2021-07-30

• MEK1/2 Inhibitor Selumetinib (AZD6244) Inhibits Growth of Ovarian Clear Cell Carcinoma in a PEA-15-dependent Manner in a Mouse Xenograft Model, 2011-12-05

• Targeting Signaling Pathways in Inflammatory Breast Cancer, 2020-09-01

• Phase II study of Radium-223 dichloride combined with hormonal therapy for hormone receptor-positive, bone-dominant metastatic breast cancer, 2019-12-18

• Adding hormonal therapy to chemotherapy and trastuzumab improves prognosis in patients with hormone receptor-positive and human epidermal growth factor receptor 2-positive primary breast cancer, 2012-11-27

• Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination, 2014-09-16

• Prognostic Impact of High Baseline Stromal Tumor-Infiltrating Lymphocytes in the Absence of Pathologic Complete Response in Early-Stage Triple-Negative Breast Cancer, 2022-03-04

• Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a, 2015-11-21

• JNK Signaling in Stem Cell Self-Renewal and Differentiation, 2020-04-09

• PTEN in triple-negative breast carcinoma: protein expression and genomic alteration in pretreatment and posttreatment specimens, 2023-08-02

• Predictive Roles of Baseline Stromal Tumor-Infiltrating Lymphocytes and Ki-67 in Pathologic Complete Response in an Early-Stage Triple-Negative Breast Cancer Prospective Trial, 2023-06-21

• Histone Deacetylase Inhibitors Stimulate Dedifferentiation of Human Breast Cancer Cells through WNT/ß-catenin Signaling, 2015-02-19

• A Multi-Center Clinical Study to Harvest and Characterize Circulating Tumor Cells from Patients with Metastatic Breast Cancer Using the Parsortix®PC1 System, 2022-10-26

• Differential radiosensitizing effect of valproic acid in differentiation versus self-renewal promoting culture conditions, 2010-03-01

• Outcomes in Early-Stage Breast Cancer Patients Who Underwent a 21-Gene Expression Assay, 2017-02-15

• Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells, 2010-07-08

• Changes in Overall Survival over Time for Patients with de novo Metastatic Breast Cancer, 2021-05-28

• Immune Phenotype and Response to Neoadjuvant Therapy in Triple-Negative Breast Cancer, 2021-10-01

• Landscape of somatic mutations in 560 breast cancer whole genome sequences, 2016-05-02

• Histone deacetylase inhibitor enhances the efficacy of MEK inhibitor through NOXA-mediated MCL1 degradation in triple-negative and inflammatory breast cancer, 2017-05-02

• Androgen receptor expression on circulating tumor cells in metastatic breast cancer, 2017-09-28

• Challenges and perspective of drug repurposing strategies in early phase clinical trials, 2015-06-30

• High-Density and Very-Low-Density Lipoprotein Have Opposing Roles in Regulating Tumor-Initiating Cells and Sensitivity to Radiation in Inflammatory Breast Cancer, 2015-04-01

• Genomic and Expression Analysis of Microdissected Inflammatory Breast Cancer, 2013-04-09

• Antagonism of Tumoral Prolactin Receptor Promotes Autophagy Related Cell Death, 2014-04-03

• Pathological complete response of adding targeted therapy to neoadjuvant chemotherapy for inflammatory breast cancer: A systematic review, 2021-04-16

• Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes, 2013-08-15

• The Prognostic Impact of Body Composition for Locally Advanced Breast Cancer Patients Who Received Neoadjuvant Chemotherapy, 2021-02-04

• Prognosis for patients with metastatic breast cancer who achieve ‘no-evidence-of-disease' status after systemic or local therapy, 2015-09-08

• Birinapant Enhances Gemcitabine's Anti-tumor Efficacy in Triple-Negative Breast Cancer by Inducing Intrinsic Pathway-Dependent Apoptosis, 2020-12-15

• Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype?, 2015-05-07

• Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment, 2011-06-15

• Survival Outcomes byTP53Mutation Status in Metastatic Breast Cancer, 2018-04-25

• A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer, 2022-02-15

• Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling, 2022-04-04

• Estrogen receptor ß-mediated inhibition of actin-based cell migration suppresses metastasis of inflammatory breast cancer, 2021-01-29

• CSF-1/CSF-1R axis is associated with epithelial/mesenchymal hybrid phenotype in epithelial-like inflammatory breast cancer, 2018-06-21

• Validation of Prognostic Stage and Anatomic Stage in the American Joint Committee on Cancer 8th Edition for Inflammatory Breast Cancer, 2020-10-24

• Role of Epidermal Growth Factor Receptor in Breast Cancer, 2012-10-17

• Improvement of survival and prospect of cure in patients with metastatic breast cancer, 2011-05-13

• Whole-genome sequencing of phenotypically distinct inflammatory breast cancers reveals similar genomic alterations to non-inflammatory breast cancers, 2021-04-26

• Clinical outcomes based on multigene profiling in metastatic breast cancer patients, 2016-10-28

• Distinct epidemiological profiles associated with inflammatory breast cancer (IBC): A comprehensive analysis of the IBC registry at The University of Texas MD Anderson Cancer Center, 2018-09-24

• Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype, 2019-09-18

• Outcomes after Multidisciplinary Treatment of Inflammatory Breast Cancer in the Era of Neoadjuvant HER2-Directed Therapy, 2013-09-25

• Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux, 2018-11-20

• A Novel Immunomodulatory 27-Gene Signature to Predict Response to Neoadjuvant Immunochemotherapy for Primary Triple-Negative Breast Cancer, 2021-09-28

• Phenotypic Plasticity in Circulating Tumor Cells Is Associated with Poor Response to Therapy in Metastatic Breast Cancer Patients, 2023-03-06

• Functional consequence of theMET-T1010I polymorphism in breast cancer, 2014-12-31

• Patient reported outcomes can improve performance status assessment: a pilot study, 2019-07-16

• TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase, 2013-09-06

• A Prospective Study of Bone Tumor Response Assessment in Metastatic Breast Cancer, 2012-10-24

• Early clinical development of epidermal growth factor receptor targeted therapy in breast cancer, 2017-03-08

• Different Biological Processes are Associated with the Different Molecular Subtypes of Inflammatory Breast Cancer, 2010-12-09

• Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers, 2013-11-25

• Mesenchymal stem cells and macrophages interact through IL-6 to promote inflammatory breast cancer in pre-clinical models, 2016-10-15

• Antitumor Activity of KW-2450 Against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases, 2015-10-06

• Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer, 2011-06-15

• Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer, 2019-03-02

• Stabilization of E-cadherin adhesions by COX-2/GSK3ßsignaling is a targetable pathway in metastatic breast cancer, 2023-03-22

• The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer, 2013-08-27

• Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer, 2018-01-04

• Identification of Kinase Targets for Enhancing the Antitumor Activity of Eribulin in Triple-Negative Breast Cell Lines, 2023-02-28

• EpCAM-independent isolation of circulating tumor cells with epithelial-to-mesenchymal transition and cancer stem cell phenotypes using ApoStream®in patients with breast cancer treated with primary systemic therapy, 2020-03-26

• Somatic mutations reveal asymmetric cellular dynamics in the early human embryo, 2017-03-22

• Poor response to neoadjuvant chemotherapy correlates with mast cell infiltration in inflammatory breast cancer, 2019-05-01

• Inflammatory breast cancer: a proposed conceptual shift in the UICC-AJCC TNM staging system, 2018-09-06

• Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer, 2015-02-21

• Bisphosphorylated PEA-15 Sensitizes Ovarian Cancer Cells to Paclitaxel by Impairing the Microtubule-Destabilizing Effect of SCLIP, 2013-03-29

• Circulating tumor cells in newly diagnosed inflammatory breast cancer, 2015-01-09

• NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non-inflammatory breast cancers F. Bertucciet al., 2020-02-05

• Epithelial-Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer, 2012-09-12

• High Serum miR-19a Levels Are Associated with Inflammatory Breast Cancer and Are Predictive of Favorable Clinical Outcome in Patients with Metastatic HER2+Inflammatory Breast Cancer, 2014-01-08

• Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion E. S. Villodreet al., 2021-08-27

• Epidemiological Risk Factors Associated with Inflammatory Breast Cancer Subtypes, 2016-01-21

• Low-dimensional dynamical characterization of human performance of cancer patients using motion data, 2018-05-18

• Rates of immune cell infiltration in patients with triple-negative breast cancer by molecular subtype, 2018-10-12

• Ink4a/Arf-/-andHRAS(G12V)transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f-quiescent cells, 2013-02-04

• Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer, 2023-06-20

• MiR-33a Decreases Radiation Sensitivity to High-density Lipoprotein in Breast Cancer, 2016-01-22

• Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells, 2015-07-24

• Hepatic Resection for Breast Cancer Liver Metastases: Impact of Intrinsic Subtypes, 2020-03-28

• Elevated serum levels of sialyl Lewis X (sLeX) and inflammatory mediators in patients with breast cancer, 2019-05-03

• EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer, 2017-07-04

• An enzymatically cleavable tripeptide linker for maximizing the therapeutic index of antibody-drug conjugates, 2022-09-06

• Molecular characterization and prospective evaluation of pathological response and outcomes with neoadjuvant therapy in metaplastic triple-negative breast cancer, 2022-07-01

• The efficacy of first-line chemotherapy in endocrine-resistant hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer., 2020-07-27

• Circulating tumor cells (CTCs) are associated with abnormalities in peripheral blood dendritic cells in patients with inflammatory breast cancer, 2016-06-25

• Development of PEA-15 using a potent non-viral vector for therapeutic application in breast cancer, 2014-10-07