Dr. Nathan Shapiro, MD

• Emergency Medicine

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• Brigham And Women's Hospital

  Residency Hospital

• Temple University Lewis Katz School Of Medicine

  Medical School, 1996

• Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance, 2020-04-21

• Opportunities for Emergency Medical Services care of sepsis, 2009-12-16

• Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock, 2018-12-21

• Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis, 2023-04-17

• High-Sensitivity C-Reactive Protein and Risk of Sepsis, 2013-07-23

• Symptoms and recovery among adult outpatients with and without COVID-19 at 11 healthcare facilities-July 2020, United States, 2021-01-06

• Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury, 2013-02-06

• The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis, 2010-10-13

• Mean arterial pressure and mortality in patients with distributive shock: a retrospective analysis of the MIMIC-III database, 2018-11-08

• Derivation of a Novel Risk Prediction Scores for Community-Acquired Sepsis and Severe Sepsis, 2016-01-27

• Association between early hyperoxia exposure after resuscitation from cardiac arrest and neurological disability: A prospective multi-center protocol-directed cohort study, 2018-02-01

• Sepsis Subclasses: A Framework for Development and Interpretation*, 2021-05-01

• Neutralizing antibody responses in patients hospitalized with SARS-CoV-2 Delta or Omicron infection, 2022-12-01

• Challenges and Opportunities for Emergency Department Sepsis Screening at Triage, 2018-07-23

• Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis, 2019-08-07

• Angiopoietin-2 may contribute to multi-organ dysfunction and death in sepsis, 2013-05-31

• Sublingual microcirculation is impaired in post-cardiac arrest patients, 2013-07-18

• Partial pressure of arterial carbon dioxide after resuscitation from cardiac arrest and neurological outcome: a prospective multi-center protocol-directed cohort study, 2018-11-16

• Prediction of bacteremia in emergency department patients with suspected infection: an external validation of a clinical decision rule, 2013-11-05

• An Emergency Department validation of the SEP-3 Sepsis and Septic Shock definitions and comparison with 1992 Consensus definitions, 2017-03-03

• Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults, 2021-03-02

• Discharge diagnoses versus medical record review in the identification of community-acquired sepsis, 2015-02-16

• Increasing number of organ dysfunctions is an excellent predictor of in-hospital mortality in emergency department patients with suspected infection: an internal and external prospective validation study, 2013-11-05

• Fluid-limiting treatment strategies among sepsis patients in the ICU: a retrospective causal analysis, 2020-02-22

• Diagnostic Accuracy of FebriDx: A Rapid Test to Detect Immune Responses to Viral and Bacterial Upper Respiratory Infections, 2017-10-07

• The glycocalyx: a novel diagnostic and therapeutic target in sepsis, 2019-01-17

• Inflammatory and Endothelial Activation Biomarkers and Risk of Sepsis: A Nested Case-Control Study, 2013-02-12

• Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults, 2021-03-20

• Analysis of Diagnoses, Symptoms, Medications, and Admissions Among Patients With Cancer Presenting to Emergency Departments Analysis of Diagnoses, Symptoms, Medications, and Admissions Among Patients With Cancer in EDs, 2019-03-22

• Liberal versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial, 2018-05-10

• Validation of the Emergency Severity Index (Version 4) for the Triage of Adult Emergency Department Patients with Active Cancer, 2019-07-26

• Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients, 2012-05-14

• Association between elevated mean arterial blood pressure and neurological outcome after resuscitation from cardiac arrest: results from a multicenter prospective cohort study, 2018-09-08

• Systematic Molecular Phenotyping: A Path Towards Precision Emergency Medicine?, 2016-10-03

• Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classifications in a Population-based Cohort: The REasons for Geographic and Racial Differences in Stroke Study, 2017-03-04

• Characteristics and Outcomes of Patients with Vasoplegic Versus Tissue Dysoxic Septic Shock, 2013-06-17

• Impact of Transfusion of Autologous 7 versus 42 day old AS-3 Red Blood Cells on Tissue Oxygenation and the Microcirculation in Healthy Volunteers, 2012-03-27

• Early Increases in Microcirculatory Perfusion During Protocol-Directed Resuscitation are Associated with Reduced Multi-Organ Failure at 24 hours in Patients with Sepsis, 2008-07-02

• Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function, 2016-01-19

• Biomarkers of endothelial cell activation in early sepsis, 2013-05-08

• The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis, 2011-09-22

• Chronic Statin Use and Long-Term Rates of Sepsis: A Population-Based Cohort Study, 2014-09-15

• Identifying Patients for Early Discharge: Performance of Decision Rules Among Patients with Acute Chest Pain, 2012-10-30

• Relationship between alternative resucitation strategies, host response and injury biomarkers, and outcome in septic shock: Analysis of the ProCESS study, 2016-11-07

• Validation of the REGARDS Severe Sepsis Risk Score, 2018-12-11

• A Multimodal Curriculum With Patient Feedback to Improve Medical Student Communication: Pilot Study, 2019-12-09

• Serial Procalcitonin predicts mortality in Severe Sepsis patients Results from the multicenter Procalcitonin MOnitoring SEpsis Study (MOSES), 2017-01-19

• Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation, 2019-07-23

• Delirium Risk Prediction, Health Care Utilization and Mortality of Elderly Emergency Department Patients, 2014-02-10

• Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19, 2021-10-22

• Lactate clearance in septic shock is not a surrogate for improved microcirculatory flow, 2016-05-11

• Ascertainment of vaccination status by self-report versus source documentation: Impact on measuring COVID-19 vaccine effectiveness, 2022-07-11

• Associations between persistent symptoms after mild COVID-19 and long-term health status, quality of life, and psychological distress, 2022-03-28

• Obesity and Risk of Sepsis: A Population-Based Cohort Study, 2013-07-05

• Trial of Early Antiviral Therapies during Non-hospitalized Outpatient Window (TREAT NOW) for COVID-19: a summary of the protocol and analysis plan for a decentralized randomized controlled trial, 2022-04-08

• THE FEASIBILITY AND ACCURACY OF POINT-OF-CARE LACTATE MEASUREMENT IN EMERGENCY DEPARTMENT PATIENTS WITH SUSPECTED INFECTION, 2009-08-31

• Derivation and Validation of Predictive Factors for Clinical Deterioration after Admission in Emergency Department Patients Presenting with Abnormal Vital Signs Without Shock, 2015-12-08

• Observation Unit Use Among Patients with Cancer Following Emergency Department Visits: Results of a Multicenter Prospective Cohort from CONCERN, 2021-12-04

• Serum Lactate Predicts Adverse Outcomes in Emergency Department Patients With and Without Infection, 2016-12-07

• Influenza Vaccine Acceptance and Hesitancy Among Adults Hospitalized with Severe Acute Respiratory Illnesses, United States 2019-2020, 2021-08-07

• Chronic Medical Conditions and Risk of Sepsis, 2012-10-31

• Analysis of Outcomes Associated With Outpatient Management of Nonoperatively Treated Patients With Appendicitis Outpatient Antibiotic Management of Appendicitis, 2022-07-01

• Endothelial Cell Activation in Emergency Department Patients with Sepsis and Non-sepsis related Hypotension, 2011-06-21