Dr. Stanley Hazen, MD

• Cardiology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Washington University

  Fellowship Hospital, 1996

• Barnes - Jewish Hospital

  Residency Hospital, 1994

• Barnes - Jewish Hospital

  Internship Hospital, 1993

• University Of Washington

  Medical School, 1992

• Plasma Myeloperoxidase Predicts Incident Cardiovascular Risks in Stable Patients Undergoing Medical Management for Coronary Artery Disease, 2010-11-08

• Serum Trimethylamine N-oxide, Carnitine, Choline and Betaine in Relation to Colorectal Cancer Risk in the Alpha Tocopherol and Beta Carotene Study, 2017-01-11

• Protein Carbamylation and Cardiovascular Disease, 2015-06-10

• Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort, 2017-04-13

• OxNASH Score Correlates with Histologic Features and Severity of Nonalcoholic Fatty Liver Disease, 2014-01-25

• No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis, 2016-10-12

• Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium, 2019-03-21

• New gene functions in megakaryopoiesis and platelet formation, 2011-11-30

• Protection of Extraribosomal RPL13a by GAPDH and Dysregulation byS-Nitrosylation, 2012-07-05

• Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities with Cardiovascular Risk, 2012-09-13

• Recipient myeloperoxidase-producing cells regulate antibody-mediated acute versus chronic kidney allograft rejection, 2021-07-08

• Impact of Individual Traits, Saturated Fat, and Protein Source on the Gut Microbiome Lang et al., 2018-12-11

• Diminished Anti-Oxidant Activity of High-Density Lipoprotein-Associated Proteins in Systolic Heart Failure, 2010-11-09

• Gut microbes impact stroke severity via the trimethylamine-N-oxide pathway, 2021-06-16

• The pattern of apolipoprotein A-I lysine carbamylation reflects its lipidation state and the chemical environment within human atherosclerotic aorta, 2022-03-15

• Dietary Metabolism, Gut Microbiota and Acute Heart Failure, 2016-03-15

• Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium, 2019-04-16

• Neutrophils, Hypercholesterolemia and Atherogenesis, 2010-10-18

• Carbamylated Low Density Lipoprotein and Thrombotic Risk in Chronic Kidney Disease, 2016-10-11

• Microbiome, TrimethylamineN-Oxide (TMAO), and Cardiometabolic Disease, 2016-07-18

• Increased TrimethylamineN-oxide (TMAO) Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus, 2016-11-18

• Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk, 2009-06-02

• The Gut Microbiome and its Role in Cardiovascular Diseases, 2017-03-14

• Probiotic Therapy to Attenuate Weight Gain and Trimethylamine N-oxide (TMAO) Generation: A Cautionary Tale, 2015-10-14

• Cytokeratin 18 Fragment Levels as a Noninvasive Biomarker for Nonalcoholic Steatohepatitis in Bariatric Surgery Patients, 2008-07-26

• Clinical and Genetic Association of Serum Ceruloplasmin with Cardiovascular Risk, 2011-11-10

• Relation of Red Cell Distribution Width to Left Ventricular End-Diastolic Pressure and Mortality in Patients with and without Heart Failure, 2017-02-10

• Triglyceride Levels and Not Adipokine Concentrations Are Closely Related to severity of Nonalcoholic Fatty Liver Disease in an Obesity surgery Cohort, 2009-04-09

• HDL and Atherosclerosis Regression: Evidence from Pre-clinical and Clinical Studies, 2014-01-03

• A Cardiovascular Disease-Linked Gut Microbial Metabolite ActsviaAdrenergic Receptors, 2020-03-05

• Dietary meat, trimethylamine N-oxide-related metabolites, and incident cardiovascular disease among older adults: the Cardiovascular Health Study, 2022-08-01

• The TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance, 2015-01-15

• Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials, 2016-01-12

• NMR Quantification of Trimethylamine-N-oxide in Human Serum and Plasma in the Clinical Laboratory Setting, 2017-06-15

• Protein Carbamylation in Chronic Systolic Heart Failure: Relation to Renal Impairment and Adverse Long-Term Outcomes, 2013-03-19

• Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease, 2023-10-12

• Trimethylamine N-Oxide levels are associated with NASH in obese subjects with type 2 diabetes, 2020-08-10

• The Function and Distribution of Apolipoprotein A1 in the Artery Wall are Markedly Distinct from those in Plasma, 2013-08-22

• Microbiome series Microbial modulation of cardiovascular disease, 2018-01-08

• An abundant dysfunctional apolipoprotein A1 in human atheroma, 2014-01-26

• Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism, 2015-10-31

• Plasma TrimethylamineN-oxide, a Gut Microbe-Generated Phosphatidylcholine Metabolite, is Associated with Atherosclerotic Burden, 2016-06-07

• Gut Microbe-Generated TMAO from Dietary Choline Is Prothrombotic in Subjects, 2017-04-25

• Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease, 2014-07-17

• Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome, 2011-09-29

• Association of a Genetic Risk Score with Prevalent and Incident Myocardial Infarction in Subjects Undergoing Coronary Angiography, 2012-07-05

• First eight residues of apolipoprotein A-I mediate the C-terminus control of helical bundle unfolding and its lipidation, 2020-01-16

• Risk Prediction with Serial Myeloperoxidase Monitoring in Patients with Acute Chest Pain, 2011-09-22

• Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-oxide in Patients with Heart Failure: Refining the Gut Hypothesis, 2014-10-27

• Immunoglobulins against Tyrosine Nitrated Epitopes in Coronary Artery Disease, 2012-10-18

• Subclinical Myocardial Necrosis and Cardiovascular Risk in Stable Patients Undergoing Elective Cardiac Evaluation, 2009-12-23

• The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 (FMO3) Regulates Obesity and the Beiging of White Adipose Tissue, 2017-06-20

• Two Chromosome 9p21 Haplotype Blocks Distinguish Between Coronary Artery Disease and Myocardial Infarction Risk, 2013-05-31

• Usefulness of Elevated Urine Neopterin Levels In Assessing Cardiac Dysfunction AND Exercise Ventilation Inefficiency in Patients with Chronic Systolic Heart Failure, 2014-03-18

• Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer, 2017-06-27

• Dietary Choline Supplements, but Not Eggs, Raise Fasting TMAO Levels in Participants with Normal Renal Function: A Randomized Clinical Trial, 2021-04-17

• The utility of biomarkers in diagnosis of aspirin exacerbated respiratory disease, 2018-10-30

• ?-Butyrobetaine is a pro-atherogenic intermediate in gut microbial metabolism ofL-carnitine to TMAO, 2014-11-04

• HDL Function, Dysfunction, and Reverse Cholesterol Transport, 2012-11-07

• Congruency between biophysical data from multiple platforms and molecular dynamics simulation of the double super helix model of nascent high-density lipoprotein, 2010-08-31

• Genetic deficiency of flavin containing monooxygenase 3 (Fmo3) protects against thrombosis but has only a minor effect on plasma lipid levels, 2019-04-01

• Biomarker-based Asthma Phenotypes of Corticosteroid Response, 2014-12-06

• PI(4,5)P2 is translocated by ABCA1 to the cell surface where it mediates apolipoprotein A1 binding and nascent HDL assembly, and it is carried on HDL, 2016-08-11

• Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data, 2019-04-16

• Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity, 2011-05-04

• Age andAPOEaffect L-carnitine system metabolites in the brain in the APOE-TR model, 2023-01-06

• Gut Microbiota in Cardiovascular Health and Disease, 2017-03-31

• Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, 2011-04-07

• A Genome Wide Association Study for Coronary Artery Disease Identifies a Novel Susceptibility Locus in the Major Histocompatibility Complex, 2012-02-07

• Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression, 2020-12-01

• Seventy-five genetic loci influencing the human red blood cell, 2012-12-05

• Common Variants inKCNN3are Associated with Lone Atrial Fibrillation, 2010-02-21

• An interleukin-23- interleukin-22 axis regulates intestinal microbial homeostasis to protect from diet-induced atherosclerosis, 2018-10-30

• Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice, 2021-01-12

• High Betaine, a Trimethylamine N-Oxide Related Metabolite, Is Prospectively Associated with Low Future Risk of Type 2 Diabetes Mellitus in the PREVEND Study, 2019-11-01

• Oxidation increases mucin polymer cross-links to stiffen airway mucus gels, 2015-02-25

• Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data., 2020-07-13

• Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk, 2016-12-20

• Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production, 2022-01-13

• Plasma trimethylamineN-oxide (TMAO) levels predict future risk of coronary artery disease in apparently healthy individuals in the EPIC-Norfolk Prospective Population Study, 2021-02-21

• Nitrated fibrinogen is a biomarker of oxidative stress in venous thromboembolism, 2012-05-10

• Longitudinal associations of plasma TMAO and related metabolites with cognitive impairment and dementia in older adults: the Cardiovascular Health Study, 2022-10-05

• Association of TrimethylamineN-Oxide and Related Metabolites in Plasma and Incident Type 2 Diabetes The Cardiovascular Health Study TrimethylamineN-Oxide and Related Metabolites in Plasma and Incident Diabetes, 2021-08-27

• Usefulness of Myeloperoxidase Levels in Healthy Elderly Subjects to Predict Risk of Developing Heart Failure, 2009-03-13

• Choline Diet and Its Gut Microbe Derived Metabolite, Trimethylamine N-Oxide (TMAO), Exacerbate Pressure Overload-Induced Heart Failure, 2015-12-23

• Multiple rare alleles atLDLRandAPOA5confer risk for early-onset myocardial infarction, 2014-12-10

• Gut microbiota involvement in ventricular remodeling post myocardial infarction: New insights into how to heal a broken heart, 2019-01-29

• Gut microbiota-dependent metabolite trimethylamineN-oxide (TMAO) and cardiovascular risk in patients with suspected functionally relevant coronary artery disease (fCAD), 2022-02-26

• Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis, 2018-06-08

• Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-oxide, a Pro-Atherogenic Metabolite of Choline and L-Carnitine, 2014-03-27

• Advances in new therapeutic targets for atherosclerosis, 2017-01-17

• Prognostic Comparison of Different Sensitivity Cardiac Troponin Assays in Stable Heart Failure, 2014-10-15

• The Nutritional SupplementL-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis, 2021-12-15

• Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice, 2022-01-27

• Novel Risk Stratification Assays for Acute Coronary Syndrome, 2018-06-06

• Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism, 2012-04-28

• Predicting Long-Term Prognosis in Stable Peripheral Artery Disease with Baseline Functional Capacity Estimated by The Duke Activity Status Index, 2016-10-20

• Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure, 2008-08-06

• Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes, 2023-07-25

• Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus, 2020-08-13

• Adrenal-permissiveHSD3B1genetic inheritance and risk of estrogen-driven postmenopausal breast cancer, 2021-10-22

• Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease, 2012-02-16

• Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation, 2010-03-21

• Non-Linear Relationship between Anti-Apolipoprotein A-1 IgGs and Cardiovascular Outcomes in Patients with Acute Coronary Syndromes, 2019-07-09

• Breathprints of Childhood Obesity: Changes in Volatile Organic Compounds in Obese Children Compared to Lean Controls, 2014-03-27

• The microbialgbugene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism, 2021-12-23

• Dual role of the leukocyte integrin aMß2in angiogenesis, 2014-09-26

• Quantification of Fatty Acid Oxidation Products Using On-line High Performance Liquid Chromatography Tandem Mass Spectrometry, 2013-03-14

• Myeloperoxidase Levels Predict Accelerated Progression of Coronary Atherosclerosis in Diabetic Patients: Insights from Intravascular Ultrasound, 2013-12-19

• Target-selective ProteinS-Nitrosylation by Sequence Motif Recognition, 2014-10-16

• Intestinal Microbiota in Cardiovascular Health and Disease:JACCState-of-the-Art Review, 2019-04-30

• Circulating trimethylamineN-oxide levels following fish or seafood consumption, 2022-02-03

• Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice, 2021-07-21

• Systems Genetics Analysis of GWAS reveals Novel Associations between Key Biological Processes and Coronary Artery Disease, 2015-05-14

• Diminished Antioxidant Activity of High-Density Lipoprotein-Associated Proteins in Chronic Kidney Disease, 2013-04-24

• Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling, 2017-04-12

• Efficient site-specific prokaryotic and eukaryotic incorporation of halotyrosine amino acids into proteins, 2020-02-10

• Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease, 2016-01-29

• Prognostic Value of Estimating Functional Capacity Using the Duke Activity Status Index in Stable Patients with Chronic Heart Failure, 2014-08-28

• Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults, 2019-01-16

• Dietary metabolism, the gut microbiome, and heart failure, 2019-01-29

• Genetic contribution of the leukotriene pathway to coronary artery disease, 2011-02-04

• Gut microbiota-dependent TMAO predicts risk of cardiovascular events in patients with stroke and is related to proinflammatory monocytes, 2018-06-27

• A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease, 2015-09-07

• Saturated fatty-acids regulate retinoic acid signaling and suppress tumorigenesis by targeting fatty-acid-binding protein 5, 2015-11-23

• Effects of native and myeloperoxidase-modified apolipoprotein A-I on reverse cholesterol transport and atherosclerosis in mice, 2014-01-09

• Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation, 2015-09-21

• Nitric Oxide Bioavailability and Adiponectin Production in Chronic Systolic Heart Failure: Relation to Severity of Cardiac Dysfunction, 2013-03-13

• Usefulness of Cardiac Biomarker Score for Risk Stratification in Stable Patients Undergoing Elective Cardiac Evaluation Across Glycemic Status, 2012-12-04

• Protein Backbone and Average Particle Dynamics in Reconstituted Discoidal and Spherical HDL Probed by Hydrogen Deuterium Exchange and Elastic Incoherent Neutron Scattering, 2020-01-10

• A novel recurrent COL5A1 genetic variant is associated with a dysplasia-associated arterial disease exhibiting dissections and fibromuscular dysplasia, 2020-09-17

• Contribution of Gut Bacteria to Lipid Levels: Another Metabolic Role for Microbes?, 2015-10-09

• Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism, 2020-05-12

• Carbamylation-Dependent Activation of T Cells: A Novel Mechanism in the Pathogenesis of Autoimmune Arthritis, 2010-05-19

• Intestinal microbiota metabolism ofL-carnitine, a nutrient in red meat, promotes atherosclerosis, 2013-04-07

• Usefulness of Relative Hypochromia in Risk Stratification for Non-Anemic Patients with Chronic Heart Failure, 2016-01-28

• Gut microbiota and cardiovascular disease, 2020-07-30

• Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains, 2015-12-22

• Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis, 2015-12-17

• Diminished Global Arginine Bioavailability as a Metabolic Defect in Chronic Systolic Heart Failure, 2013-01-09

• Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study of Individual Participant Data, 2019-03-21

• Association of TrimethylamineN-Oxide and Metabolites With Mortality in Older Adults Association of TrimethylamineN-Oxide and Metabolites With Mortality in Older Adults, 2022-05-20

• Large-scale association analyses identifies 13 new susceptibility loci for coronary artery disease, 2011-03-06

• Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk, 2016-03-10

• Microbial Transplantation with Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential, 2018-10-26

• Prognostic Value of Elevated Serum Ceruloplasmin Levels in Patients with Heart Failure, 2014-08-13

• Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction and Adverse Clinical Outcomes in Chronic Systolic Heart Failure, 2014-11-20

• Gut Microbiome-Dependent Metabolic Pathways and Risk of Lethal Prostate Cancer: Prospective Analysis of a PLCO Cancer Screening Trial Cohort, 2021-10-28

• Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo, 2017-01-06

• Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data, 2019-02-19

• 2H2O-Based HDL Turnover Method for the Assessment of Dynamic HDL Function in Mice, 2013-06-13

• High-density Lipoprotein Associated Paraoxonase-1 Activity for Prediction of Adverse Outcomes in Outpatients with Chronic Heart Failure, 2017-02-07

• Dysregulated Arginine Metabolism and Importance of Compensatory Dimethylarginine Dimethylaminohydrolase-1 in Pulmonary Hypertension Associated with Advanced Systolic Heart Failure, 2012-03-27

• Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT / EDIC Study, 2018-05-09

• Development of a gut microbe-targeted non-lethal therapeutic to inhibit thrombosis potential, 2018-08-06

• Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms, 2022-01-24

• Intestinal Microbiota-Produced Trimethylamine-N-oxide and its Association with Coronary Stenosis and HIV Serostatus, 2016-05-01

• Cystatin C Identifies Patients with Stable Chronic Heart Failure at Increased Risk for Adverse Cardiovascular Events, 2012-08-16

• Prognostic value of subclinical myocardial necrosis using high-sensitivity cardiac troponin T in patients with prediabetes, 2021-08-21

• Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation, 2013-01-08

• Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry, 2014-04-01

• Noninvasive markers of airway inflammation in asthma, 2009-03-13

• Targeted inhibition of gut microbial TMAO production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic kidney disease, 2020-03-26

• Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression, 2014-05-10