Dr. Jeffrey Perlman, MD

• Endocrinology, Diabetes & Metabolism

• Internal Medicine

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• New York-presbyterian Hospital/weill Cornell Medical Center

  Fellowship Hospital, 1995

• New York-presbyterian Hospital/memorial Sloan Kettering Cancer Center

  Fellowship Hospital, 1992

• Mt. Sinai Medical Center

  Internship Hospital, 1983

• University Of Pittsburgh School Of Medicine

  Medical School, 1982

• Johns Hopkins School Of Medicine

  Undergraduate School, 1976

• Johns Hopkins University

  Undergraduate School, 1976

• English

• Hindi

• Bucci E, Fronticelli C, Flanigan K, Perlman J, Steiner RF: Fluorescence anisotropy decay studies upon hemoglobin A and its subunits. Biopolymers 1979 May; 18(5):1261-76.

• Endocrinology, Third Edition, edited by Leslie J. deGroot Principles of Hormone Action, Second Messenger Signaling Pathways: Phosphatidylinositol and Calcium, 1995

• Colson AO, Perlman JH, Jinsi-Parimoo A, Nussenzveig DR, Osman R, Gershengorn MC: A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotrophin-releasing hormone receptor in an inactive conformation. Mol Pharmacol 1998 Dec; 54(6):968-78

• Perlman JH, Colson AO, Wang W, Bence K, Osman R, Gershengorn MC: Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotrophin-releasing hormone receptor. J Biol Chem 1997 May; 272(18):11937-42

• Perlman JH, Laakkonen L, Osman R, Gershengorn MC: Distinct roles for arginines in transmembrane helices 6 and 7 of the thyrotrophin-releasing hormone receptor. Mol Pharmacol 1995 Mar; 47(3):480-4

• Jain R, Singh J, Perlman JH, Gershengorn MC: Synthesis and biology of new TRH analogues. Bioorg Med Chem 2002 Jan; 10(1):189-94

• Perlman JH, Colson AO, Jain R, Czyzewski B, Cohen LA, Osman R, Gershengorn MC: Role of the extracellular loops of the thyrotrophin-releasing hormone receptor: evidence for an initial interaction with thyrotrophin-releasing hormone. Biochemistry 1997 Dec 16; 36(50):15670-6

• Perlman JH, Laakkonen L, Thaw CN, Osman R, Gershengorn MC: Analysis of the role of transmembrane helix three of the thyrotrophin-releasing hormone (TRH) receptor in directly binding TRH. Trans Assoc Am Physicians 1993; 106:162-7.

• Perlman JH, Thaw CN, Laakkonen L, Bowers CY, Osman R, Gershengorn MC: Hydrogen bonding interactions of thyrotrophin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor. J Biol Chem 1994; 269(3):1610-3

• Perlman JH, Laakkonen L, Osman R, Gershengorn MC: A model of the thyrotrophin-releasing hormone (TRH) receptor binding pocket. Evidence for a second direct interaction between transmembrane helix 3 and TRH. J Biol Chem 1994 Sep 23; 269(38):23383-6.

• Laakkonen LJ, Guarnieri F, Perlman JH, Gershengorn MC, Osman R: A refined model of the thyrotrophin-releasing hormone (TRH) receptor binding pocket. Novel mixed mode Monte Carlo/stochastic dynamics simulations of the complex between TRH and TRH receptor. Biochemistry 1996 Jun 18; 35(24):7651-63

• Perlman JH, Nussenzveig DR, Osman R, Gershengorn MC: Thyrotrophin-releasing hormone binding to the mouse pituitary receptor does not involve ionic interactions. A model for neutral peptide binding to G protein-coupled receptors. J Biol Chem 1992 Dec 5; 267(34):24413-7

• Perlman JH, Wang W, Nussenzveig DR, Gershengorn MC: A disulfide bond between conserved extracellular cysteines in the thyrotrophin-releasing hormone receptor is critical for binding. J Biol Chem 1995 Oct 20; 270(42):24682-5

• Chu W, Perlman JH, Gershengorn MC, Moeller KD: Thyrotrophin-releasing hormone analogs: a building block approach to the construction of tetracyclic peptidomimetics. Bioorg Med Chem Lett 1998 Nov 3; 8(21):3093-6

• Colson AO, Perlman JH, Smolyar A, Gershengorn MC, Osman R: Static and dynamic roles of extracellular loops in G protein-coupled receptors: a mechanism for sequential binding of thyrotrophin-releasing hormone to its receptor. Biophys J 1998 Mar; 74(3):1087-1100

• Rutledge LD, Perlman JH, Gershengorn MC, Marshall GR, Moeller KD: Conformationally restricted TRH analogs: a probe for the pyroglutamate region. J Med Chem 1996 Apr 12; 39(8):1571-4

• Perlman JH, Gershengorn MC: Thyrotrophin-releasing hormone stimulation of phosphoinositide hydrolysis desensitizes. Evidence against mediation by protein kinase C or calcium. Endocrinology 1991 Nov; 129(5):2679-86

• Laakkonen L, Li W, Perlman JH, Guarnieri F, Osman R, Moeller KD, Gershengorn MC: Restricted analogs provide evidence of a biologically active conformation of thyrotrophin-releasing hormone. Mol Pharmacol 1996 Jun; 49(6):1092-6

• Perlman JH, Laakkonen LJ, Guarnieri F, Osman R, Gershengorn MC: A refined model of the thyrotrophin-releasing hormone (TRH) receptor binding pocket. Experimental analysis and energy minimization of the complex between TRH and TRH receptor. Biochemistry 1996 Jun 18; 35(24):7643-50